Pharmacological Treatment of Bladder Dysfunction
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چکیده
Above ureteric orifices 3 layers – adventitia, smooth muscle, and urothelium. Haphazard arrangement of smooth muscle myofibrils. Acts as functional syncytium. No specific gap junctions, but ‘areas of close proximity’ 2 main populations of receptors, cholinergic (muscarinic) and adrenergic Muscarinic subtypes M2 and M3 in bladder smooth muscle. M2 80% population, but M3 functionally important Adrenergic subtypes β1 and β2 Afferent nociceptive impulses via pelvic nerves to S2/3/4
منابع مشابه
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تاریخ انتشار 2011